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Maternal caloric restriction during late gestation reduces birth weight, but whether long term adverse metabolic outcomes of intra uterine growth retardation (IUGR) are dependent on either accelerated postnatal growth or exposure to an obesogenic environment after weaning is not established. We induced IUGR in twin pregnant sheep using a 40% maternal caloric restriction commencing from 110 days of gestation until term (147 days), compared with mothers fed to 100% of requirements. Offspring were reared either as singletons to accelerate postnatal growth or as twins to achieve standard growth.

The testing of redundant systems is difficult because of their complexity steroids, and under certain circumstances the redundancy can mask design faults. Testing methods using complex test equipment are described, as well as the testing of the experimental controller. A review is included of other fault tolerant systems.

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