An increase in the relative abundance of transcripts of both

The bioadhesive polymers used were Carbopol 974P NF (CBP), hydroxypropyl methylcellulose 2910 (HPMC), poly(vinylpyrrolidone) K30 (PVP) and carboxymethyl chitosan (CMCTS). Two self fabricated methods using the texture analyser (tensile and shear stress) were developed to study bioadhesion of suppositories against porcine colon mucosa under simulated rectal conditions.Physical characterisation found that CE and SS were comparable to CB in terms of thermal profile, solid fat content (SFC), pH, viscosity and displacement values (DV) but with added advantages of reduced polymorphism and less stringent manufacturing parameters. Solidification of CB melt into suppositories was highly dependent on the maximum heating temperature (Tmax) and cooling rate (Crate).

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